Welcome to anan-AB
Your Partner in Antibody Solutions
Our Services
Explore our extensive suite of antibody-centric services. Delve into custom antibody development powered by advanced phage-display technology, or enhance the expression and binding affinity of antibodies tailored for both scientific research and clinical applications.
Custom Antibody Development
Our custom antibody development services utilize cutting-edge phage-display technology to generate high-quality antibodies tailored to your specific needs.
Improvement of Antibody Expression
The protein sequence is the key factor determining the expression of a protein. Certain amino acid residues can influence the expression of key antibodies. Our specialized service enhances the expression of vital antibodies by meticulously optimizing crucial amino acid sequences.
Potential factors impacting the expression of antibodies
Maturation of Binding Affinity
By integrating structural biology with phage-display technology, we can improve potential protein interactions. This approach allows us to significantly enhance the binding affinity of specific antibodies, elevating their performance to picomolar (pM) levels. Such enhancements are not just incremental; they are crucial for ensuring the efficacy and reliability of antibodies in clinical applications, setting the stage for transformative breakthroughs in patient care. Protein interactions are shown below.
Hydrophobic Interactions
Hydrogen Bonds
Salt Bridges
Steric Effects
Antibody Humanization: CDR-grafting
Leveraging the technique of CDR-grafting, we transfer Complementarity-Determining Regions (CDRs) from mouse antibodies onto a human framework, incorporating essential back mutations to ensure optimal functionality.
Antibody Humanization: Fully-humanized
Our full-humanization process employs phage-display technology to meticulously screen variable regions of human light and heavy chains from our extensive human library. Post-selection, we undertake a rigorous triple-verification to ensure that the fully humanized antibody consistently targets the precise epitope.
